VR46 Ducati rider Marco Bezzecchi posted in the all-important last lap to top the final MotoGP practice session at Misano.
The GP23 Ducati rider crafted the quickest lap time of 1.31.237s, with GP24 Ducati and championship protagonists Francesco Bagnaia and Jorge Martin rounding off the top three positions.
Enea Bastianini and Franco Morbidelli displayed their quick pace in the final session, with both GP24 teams inside the top five.
Pol Espargaro finished the session as the highest non Ducati rider, with Gresini rider Marc Marquez close behind.
Rookie Pedro Acosta ended his session in the eighth spot, with fellow Gresini rider and younger brother Alex Marquez two tenths adrift of the GasGas rider.
Ninth to 12th place was separated by only 0.013s, with the GP23 Ducati, Aprilia, Yamaha and KTM occupying these spots.
Aleix Espargaro finished as the lead Aprilia rider and ended the session in tenth, with Yamaha’s Fabio Quartararo feeling optimistic about configuring a solid result in Misano.
Brad Binder finished his session with only 0.001s separating himself and the Frenchman, with VR46 rider Fabio Di Giannantonio in 13th spot.
Miguel Oliveira once again finished as lead Trackhouse rider, with KTM’s Jack Miller finishing his session in 15th respectively.
Maverick Vinales’ struggles aboard the current Aprilia continue, with the Spaniard finishing in a lonely 16th spot ahead of fellow compatriot Alex Rins.
Augusto Fernandez finished in 18th spot, with the closing positions occupied by Honda riders and Raul Fernandez.
Takaaki Nakagami finished as lead Honda, with team-mate Johann Zarco only a tenth away.
Luca Marini finished behind the LCR duo, with Raul Fernandez struggling around the Misano circuit with the second-to-last spot occupied.
Honda test rider Stefan Bradl rounded off proceedings, with 2020 champion Joan Mir sitting out the whole weekend due to illness.