Mercedes are bracing themselves for a tough weekend in Mexico, with team boss Toto Wolff believing it will be their "most difficult" race of the remaining four races on the 2019 calendar.
Since the race returned in 2015, Mercedes has won it twice with Nico Rosberg claiming victory in 2015 and Lewis Hamilton the following year. But Red Bull are the 'on form' team at the Autódromo Hermanos Rodríguez where Max Verstappen has claimed victory at the last two grands prix.
But with Ferrari the on the up, Mercedes know they face an uphill challenge this weekend, where a good result for Hamilton could secure him his sixth Drivers' Championship.
"We know that the four remaining races are not going to be easy and we expect Mexico to be the most difficult one for us," said Wolff.
"The high altitude of the track brings some fairly unusual challenges as the low air density affects the downforce of the car, the cooling and the engine performance.
"It's a combination that doesn't particularly suit our car, but we will give it everything to try and limit the damage.
"We look forward to the fight and to the amazing Mexican crowd that shares our love for racing and turns the weekend into a brilliant celebration of motorsport."
Mercedes has enjoyed more success at the other three races which are yet to run, with Hamilton winning four of the last five United States GP's, two of the last three Brazilian GP's, whilst Mercedes has won the last five races in Abu Dhabi.